Stress selections on domain antibodies: 'What doesn't kill you makes you stronger'
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چکیده
منابع مشابه
Stress selections on domain antibodies: 'what doesn't kill you makes you stronger'.
In addition to the desired specificity and affinity for their respective therapeutic targets, antibody-based drugs must also demonstrate an ability to be manufactured and formulated at the concentrations needed for therapeutic application and to remain resistant to aggregation during storage to reduce the risk of induced immunogenicity. Improvements to the thermodynamic stability of the folded ...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2015
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzu057